A NEW FOUR-PARAMETER THRESHOLD MODEL FOR THE PLASMA ATRACURIUM CONCENTRATION-RESPONSE RELATIONSHIP
نویسندگان
چکیده
منابع مشابه
A new four-parameter threshold model for the plasma atracurium concentration-response relationship.
The plasma concentration of atracurium and the electromyographic depression of the first response of the train-of-four (T1:T0) were measured during and after recovery from a 10-min infusion of atracurium 0.25 mg kg-1 in 14 patients anaesthetized with 66% nitrous oxide and 0.9% isoflurane (end-tidal) in oxygen. A standard pharmaco-dynamic model was fitted to the data; a small but consistent disc...
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The electromyographic response to a short infusion of atracurium 0.25 mg kg-1 was recorded using the train-of-four (TOF) technique, and the plasma atracurium concentration profile measured, in 10 healthy patients. The TOF ratio (T4:T1) was depressed over a time course which did not conform to the predictions of an effect compartment model; the fit of such a model, when possible, was associated ...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1992
ISSN: 0007-0912
DOI: 10.1093/bja/68.6.548